Dog

Alaskan Malamute Polyneuropathy (AMPN) is a genetic neuromuscular disorder. Symptoms may include exercise intolerance, muscle atrophy mainly in the hind legs, laryngeal paralysis resulting in a change in barking and noisy breathing. The first signs of the disease appear between the ages of 3 and 19 months.

Osteogenesis imperfecta, also known as brittle bone disease, is characterised by extreme fragility of bones and teeth caused by an abnormal collagen structure.

Leukoencephalomyelopathy (LEMP) is a neurodegenerative disease characterised by a progressive loss of mobility and coordination of the limbs. The first symptoms usually appear between 1 and 3 years of age.

X-linked hypohidrotic ectodermal dysplasia is a disease characterised by missing or malformed teeth and absent sweat glands. The disease is transmitted in an X-linked recessive manner, so males carrying the mutation will all be affected. However, only females with 2 copies of the mutated allele will be affected.

Spinocerebellar ataxia (LOA) is a genetic disease of the nervous system. Affected dogs present the first signs of ataxia around the age of 6 to 12 months. The symptoms of this pathology are a loss of balance, a progressive lack of coordination until the total loss of mobility. nother test for spinocerebellar ataxia is available. For more information, consult the DOG-SCA test.

Polyneuropathy type 1 (LNP1) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Von Willebrand disease is a disease that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. This disease is inherited as a dominant trait with incomplete penetrance, which means that not all dogs carrying the vWF mutation will show clinical signs of the disease.

Polyneuropathy type 1 (LNP21) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Von Willebrand disease is a condition that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. 

Laryngeal paralysis and polyneuropathy (LPPN3) is a disease characterised by breathing difficulties, often described as noisy or hoarse breathing. Other clinical signs, which vary from dog to dog, include difficulty swallowing, changes in frequency and quality of barking, high gait, lack of muscle coordination, exercise intolerance and muscle atrophy of the limbs.