Dog

Congenital deafness in Rottweilers is a genetic disorder causing bilateral hearing loss from the first weeks of life. Affected puppies show profound deafness, without other apparent clinical signs.

This condition is associated with a mutation in the LOXHD1 gene, which plays a key role in the function of the cochlear hair cells.

Classic-like Ehlers-Danlos syndrome is a rare genetic disorder of connective tissue, linked to abnormalities of the tenascin-XB protein (gene TNXB).

The c.2900G>A (p.Gly967Asp) mutation has been identified in a reported affected dog, in combination with a second mutation in the same gene.

Clinical signs include skin fragility, hyperextensible skin, and poor wound healing.

This mutation is found at low frequency in some breeds, but its pathogenic role remains preliminary and should be interpreted with caution.

Multiple system degeneration usually begins between 9 weeks and 6 months of age. The first signs include mild tremors and stiffness of the forelimbs.
Within 3 to 4 months, symptoms worsen, with severe ataxia, spasticity, an unsteady gait, and delayed postural reactions. The disease progresses to immobility and inability to stand, often leading to euthanasia between 1 and 2 years of age.