Dog

This panel includes the essential tests to be performed for New Scotland Retriever: Cleft Lip and Palate and Syndactyly (DOG-CL/P) and Cerebellar degeneration with myositis (DOG-CDMC).

This panel includes the specific tests to be performed for Welsh Corgi: Von Willebrand type 1 (DOG-VWD1), Bobtail (DOG-LH), Brachyury (DOG-QU) and Progressive Retinal Atrophy (DOG-PRA-RCD3). 

This profile includes the essential tests to be performed in the Whippet: drug sensitivity (DOG-MDR1) and phosphofructokinase deficiency (DOG-PFKM).

This panel includes the specific tests to be performed for the Romagnol Water Dog: Benign familial juvenile epilepsy (DOG-BFJE), Progressive rod-cone degeneration (DOG-PRA-PRCD), Hyperuricosuria (DOG-HUU) and Neurodegenerative vacuolar storage disease (DOG-LSD).

Multidrug Resistance 1 is a genetic mutation in a protein that transports drugs out of the brain. This mutation causes sensitivity to certain drugs, including ivermectin and loperamide. Because of this lack of drug clearance from the brain, affected dogs experience neurological symptoms such as ataxia or even death. MDR1 can be tested for in any breed, but is most commonly found in the breeds listed below.

Laryngeal paralysis (LP) in Bull Terriers and Miniature Bull Terriers is a genetic disorder that prevents the dog from abducting the arytenoid cartilages during inspiration, leading to partial airway obstruction and breathing difficulties. Clinical signs include reduced exercise tolerance, progressive laryngeal stridor, and episodes of respiratory distress. In these two breeds, the tested genetic variant is a risk factor for early-onset LP.

Hereditary Nasal Parakeratosis (HNPK) in Labradors is a genetic disorder affecting the corneal layer of the nasal epidermis. Affected dogs show a thickened, dry, and rough nose, often with crusts and fissures, appearing at a young age. Histologically, it is characterized by diffuse parakeratotic hyperkeratosis with retention of nuclei in the stratum corneum and accumulation of proteinaceous fluids. Despite these skin symptoms, Labradors are otherwise healthy. This genetic test is patented and performed by a licensed laboratory.

Collie Eye Anomaly (CEA) is a complex inherited eye disorder affecting mainly herding breeds with Collie ancestry. It results from abnormal development of the inner eye structures, particularly the vascular and retinal layers. Clinical expression is highly variable: some dogs remain asymptomatic, while others show choroidal hypoplasia, optic nerve coloboma, microphthalmia, intraocular hemorrhage, retinal detachment, and in severe cases visual impairment or blindness.
The genetic test based on the NHEJ1 deletion is a useful breeding tool, but it does not reliably predict clinical severity or the presence of coloboma, as other genetic factors are involved. Therefore, systematic ophthalmologic examination, especially in puppies, remains essential for breeders and veterinarians.

Osteochondrodysplasia is a skeletal developmental disorder that appears very early in puppies. It causes visible bone deformities, such as shortened or curved limbs, enlarged joints, a flattened rib cage, and sometimes a shortened lower jaw. Radiographs reveal abnormalities in ossification, particularly in the epiphyses and vertebrae. Affected puppies show marked joint stiffness that decreases with age, but mobility remains limited. In the long term, osteoarthritis is common and has a lasting impact on quality of life.

This test is also recommended for the Papillon as part of the Flemish government breeding program (see the official program).

Dental-Skeletal-Retinal Anomaly (DSRA) is a rare inherited disorder in dogs affecting the teeth, skeleton, and eyes. Affected dogs develop brittle, opaque or translucent teeth, often smaller than normal and prone to fractures. Skeletal growth abnormalities may be present, leading to disproportionate body structure. Ocular involvement includes progressive retinal atrophy (PRA), causing progressive vision loss that may ultimately result in blindness.