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Hypocatalasia (or acatalasemia) is a rare genetic disorder caused by a mutation in the CAT gene, leading to a severe deficiency of catalase. This enzyme normally protects tissues against oxidative stress. The c.979G>A (p.Ala327Thr) mutation was first identified in a Beagle colony and subsequently detected in pet Beagles. A homozygous dog notably developed oral cavity gangrene with tooth loss at a young age. The disease may remain clinically silent for a long time, which highlights the importance of genetic screening in breeding dogs.
This test is also recommended for the Basset Hound as part of the Flemish government breeding program (see the official program).

In donkeys, dominant white corresponds to complete depigmentation: the animal is born with a white coat, pink skin and dark eyes. A variant in the KIT gene, c.662A>C, was identified in a donkey showing this phenotype and is considered a candidate variant associated with dominant white. The genetic test can be used to detect this variant and identify animals that carry it. However, the available data remain preliminary, as this variant was observed in only one white donkey in the study.

The amber gene causes kittens to gradually change their coat colour from black at birth to an amber colour. This change is mainly observed during the first year. The coat colour of the cat also depends on complex interactions with other genes.

The PPARD gene is involved in mechanisms related to energy metabolism, fat utilisation and muscular endurance. In racing pigeons, a recent study suggests that certain variations in this gene may be linked to race performance, particularly return speed and ranking coefficient. The CC genotype for the PPARD c.*271C>T marker is the one that stands out most favourably in the study, notably because it was observed in pigeons taking part in a larger number of races. This test can therefore provide complementary information to guide the selection of breeding birds, without replacing the assessment of the pigeon, its lineage, training and actual racing results.

Pyruvate kinase deficiency is a haemolytic anaemia that reduces the longevity of erythrocytes (red blood cells). In the domestic cat, pyruvate kinase deficiency has a wide variability in the onset and severity of clinical symptoms. Symptoms of this anaemia may include severe lethargy, weakness, weight loss, jaundice and abdominal enlargement.

This test is also recommended for the Angora turc (see the official program) and Sphynx (see the official program) as part of the Flemish government breeding program.

This profile includes the specific tests to be performed in the Sphynx: congenital myasthenic syndrome (CAT-CMS), blood type determination (CAT-BLOOD), hypertrophic cardiomyopathy type 4 (CAT-HCM4) and hypokalaemia (CAT-HK).

This panel includes four specific analyses related to coat colour: agouti (LOCUS A) (CAT-AG), brown (LOCUS B) (CAT-BROWN), colorpoint (LOCUS C) (CAT-COLORPOINT) and dilution (LOCUS D) (CAT-DILU).

This panel includes the specific tests to be performed in Lykoi: polycystic kidney disease (CAT-PKD), pyruvate kinase deficiency (CAT-PKDef), blood type determination (CAT-BLOOD) and Progressive retinal atrophy - rdAc (CAT-PRA-RDAC).

This panel includes the specific tests to be performed in Maine Coon: hypertrophic cardiomyopathy type 1 (CAT-HCM1), polycystic kidney disease (CAT-PKD), pyruvate kinase deficiency (CAT-PKDef) and spinal muscular atrophy (CAT-SMA).

This pack includes the recommended tests defined by the Flemish breeding program for l'Australian Mist: l'hypokaliémie (CAT-HK), Pyruvate kinase deficiency (CAT-PKDEF), Gangliosidosis type 2 (CAT-GM2-BUR) and Progressive retinal atrophy (CAT-PRA-RDAC).