Prekallikrein deficiency (KLKB1: c.988T>A)
Prekallikrein (PK) deficiency in dogs is a hereditary coagulation disorder characterized by a prolonged activated partial thromboplastin time (aPTT). Most affected dogs remain asymptomatic and do not show spontaneous bleeding in the absence of other coagulation abnormalities. In rare cases, hemorrhagic signs such as gastrointestinal bleeding, hematuria, or prolonged healing time after surgery may occur.
This test is also recommended for Maltese dogs as part of the breeding program of the Flemish government (see the official program).
Transmission
Autosomal recessiveBreed
Maltese, Shih Tzu



