Dog

Glycogen storage disease is a severe genetic disorder of glycogen metabolism, causing glycogen accumulation mainly in the liver. Affected dogs show severe hepatomegaly, fasting hypoglycemia, failure to thrive, and may progress to coma and death.
The G6PC gene mutation strongly reduces enzyme activity, disrupting the production of glucose from glucose-6-phosphate.
Histologically, the liver shows vacuolated hepatocytes filled with glycogen.

Progressive rod-cone degeneration is one of several forms of progressive retinal atrophy (PRA), which causes the degeneration and death of retinal cells. The main symptom is progressive vision loss from the age of 3-5 years. The test can be performed for any breed, but is particularly relevant for the breeds listed below

Cone-rod dystrophy 1 is a form of progressive retinal atrophy characterised by an early, severe and rapidly progressive loss of cone function accompanied by a progressive loss of rods.

Cone-rod dystrophy 2 is a form of progressive retinal atrophy characterised by an early, severe and rapidly progressive loss of cone function accompanied by a progressive loss of rods.

Progressive retinal atrophy 4, also known as CORD1, is a form of progressive retinal atrophy characterised by changes in the granular appearance of the fundus, followed by generalised tapetal hyperreflexia and retinal vascular attenuation with progressive extinction of the electroretinogram. CORD1 pathology is probably caused by a combination of mutations. Only the mutation in the RPGRIP1 gene is being tested.

This test is also recommended for the Miniature Poodle as part of the Flemish government breeding program

Progressive retinal atrophy is an inherited eye disease characterised by bilateral degeneration of the photoreceptor cells of the retina resulting in progressive vision loss leading to total blindness. Other mutations can cause progressive retinal atrophy. PRA1 accounts for more than 60% of diagnosed Golden Retrievers.

Progressive retinal atrophy 1 is one of several forms of progressive retinal atrophy (PRA). The degeneration of the photoreceptors leads to blindness before the age of two.

Rod-cone dysplasia 4 is one of several forms of progressive retinal atrophy (PRA). This mutation leads to the late onset of PRA, with blindness occurring after 7 years of age.