Dog

Neuroaxonal dystrophy is a genetic neurodegenerative disease. Symptoms include various neurological symptoms such as abnormal gait, loss of balance, head tremors and involuntary eye movements (nystagmus).

Leukoencephalomyelopathy is a neurodegenerative disease characterised by a progressive loss of mobility and coordination of the limbs. The first symptoms usually appear between 1 and 4 years of age.

Footpad hyperkeratosis is a genetic disease causing a proliferation of epidermal cells. The symptoms of this pathology are thickening and hardening of the pads of all four paws. The first clinical signs usually appear during the first year of life.

In puppies with CHG, thyroid function is reduced. The main symptoms are enlarged thyroid glands, goiter and growth retardation. The first clinical signs appear a few weeks after birth.

Progressive retinal atrophy is an inherited eye disease characterized by bilateral degeneration of the photoreceptor cells of the retina resulting in progressive vision loss leading to total blindness. Other mutations can cause progressive retinal atrophy. 

Myotonia congenita is a genetic disease affecting the mechanism of muscle contraction, the main symptoms of which are muscle hypertrophy, a stiff gait, difficulty swallowing and dental anomalies. Clinical signs appear within a few weeks of birth.

Dogs with POAG have elevated intraocular pressure leading to loss of vision and usually to lens luxation (PLL). The first symptoms usually appear between 4 and 6 years of age.

Cleft lip with or without cleft palate is a genetic defect in craniofacial development causing communication between the mouth and nose. The most common symptoms are choking, coughing and difficulty swallowing. Syndactyly (fusion of fingers) may also be observed.

Neuronal ceroid lipofuscinosis is a genetic disease with symptoms including behavioural changes, cognitive decline, cerebellar ataxia, dementia, seizures, nervousness, aggression, hypersensitivity to stimuli, loss of coordination, tremors, retinal degeneration, moderate visual impairment in low light, but good visual acuity in bright light. The first behavioural signs usually appear around the age of 4 to 6 years.

Spinal dysraphism is a genetic disease with symptoms present from birth. Affected puppies show neurological abnormalities including motor disorders in the hind legs. Adults show a typical abnormal gait with simultaneous movement of the hind legs or "bunny hop".