Dog

Complement factor C3 deficiency in dogs is a condition that leads to immune system failure. This condition makes affected dogs more susceptible to multiple and recurrent bacterial infections, as well as certain kidney diseases of immune origin. The gene involved in this pathology is the C3 gene, with a specific mutation identified as c.2136delC. The frequency of carriers of this mutation is approximately 1%, and symptoms can appear from a very young age.

Globoid cell leukodystrophy, also known as Krabbe's disease, is a disorder of lipid storage in the central nervous system leading to progressive neurological degeneration. The first symptoms are ataxia and paresis of the hind legs occurring between 1 and 3 months of age, after which muscle atrophy is observed. Affected animals are usually euthanised due to lack of treatment.

Pyruvate dehydrogenase is an important enzyme for the production of energy by cells. Pyruvate dehydrogenase deficiency is therefore characterised by an intolerance to effort and lactic acidosis. Neurological complications are possible.

Gangliosidosis is a genetic defect that causes the storage of GM1 gangliosides in various tissues. The clinical signs of the disease are progressive neurological dysfunction and growth retardation

Gangliosidosis is a genetic defect that causes the storage of GM1 gangliosides in various tissues. The clinical signs of the disease are progressive neurological dysfunction and growth retardation

Gangliosidosis is a genetic defect that causes the storage of GM1 gangliosides in various tissues. The clinical signs of the disease are progressive neurological dysfunction and growth retardation

Golden Retriever muscular dystrophy is a homologue of Duchenne muscular dystrophy in humans. Affected dogs develop clinical signs at 8 to 10 weeks of age. Symptoms include a shuffling gait, inability to fully open the jaw, difficulty eating, curvature of the spine and ribs, resulting in a squatted posture. he disease is transmitted in an X-linked recessive manner, so males carrying the mutation will all be affected. However, only females with 2 copies of the mutated allele will be affected.

Haemophilia B, also known as factor IX deficiency, is a bleeding disorder. The clinical signs are haematomas and excessive bleeding due to the absence of functional coagulation factor IX.  he disease is transmitted in an X-linked recessive manner, so males carrying the mutation will all be affected. However, only females with 2 copies of the mutated allele will be affected.

Cataracts are one of the leading causes of blindness in dogs. This test highlights a mutation in the HSF4 gene that is considered a risk factor for the development of cataracts.

Cataracts are one of the leading causes of blindness in dogs. This test highlights a mutation in the HSF4 gene that is considered a risk factor for the development of cataracts.