CCDC39-related primary ciliary dyskinesia is an inherited disorder described in the Old English Sheepdog. It causes dysfunction of motile cilia, resulting in ineffective mucociliary clearance that promotes recurrent or persistent respiratory infections. Affected dogs show signs from the first days of life, including chronic nasal discharge, productive cough, sometimes fever, leukocytosis and bronchopneumonia. The mutation has been identified in both European and non-European populations of the breed, with a higher proportion of carriers in the European populations studied.
