Increased susceptibility to Mycobacterium avium complex infection is a hereditary immunodeficiency described in Miniature Schnauzers. Associated with a variant in the CARD9 gene and inherited as an autosomal recessive trait, it predisposes homozygous dogs to progressive systemic infections. Reported signs mainly include enlarged lymph nodes, as well as anorexia, lethargy, diarrhoea and fever. In the available study, age at diagnosis ranged from 1.5 to 8 years, with a median of 2.5 years; screening for the CARD9 variant is recommended in the breed to help reduce the birth of dogs at risk.

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