Search results for: 'DOG-PRA-PRCD'

Imerslund-Gräsbeck syndrome is characterised by malabsorption of vitamin B12 (cobalamin). The first symptoms appear around 6 to 12 weeks. The clinical signs are due to the lack of cobalamin which causes megaloblastic anaemia and neurological symptoms.

Neonatal interstitial lung disease is a genetic disease affecting the pulmonary system and causing lethal hypoxic respiratory failure in the first weeks of life. Other symptoms include lethargy, refusal to suckle and breathing difficulties ('dyspnea' or tachypnea).

Exfoliative cutaneous lupus erythematosus is a genetic skin disease whose symptoms are erythema, scabbing, alopecia and scaling of the skin. The first signs of the disease usually appear during the first year.

Glanzmann's thrombasthenia is an inherited bleeding disorder caused by a defect in the platelet glycoprotein αIIbβ3, which is essential for platelet aggregation.
Without this functional glycoprotein, the platelet plug forms poorly, leading to excessive bleeding after trauma or surgical procedures.

Dystrophic epidermolysis bullosa is caused by an abnormality in collagen synthesis and is characterised by the presence of blisters at the dermal-epidermal junction leading to epidermal detachment. Affected puppies show skin lesions and ulcers.

Myotonia congenita is a genetic disease affecting the mechanism of muscle contraction, the main symptoms of which are muscle hypertrophy, a stiff gait, difficulty swallowing and dental anomalies. Clinical signs appear within a few weeks of birth.

Osteogenesis imperfecta, also known as brittle bone disease, is characterised by extreme fragility of bones and teeth caused by an abnormal collagen structure.

Spinal dysraphism is a genetic disease with symptoms present from birth. Affected puppies show neurological abnormalities including motor disorders in the hind legs. Adults show a typical abnormal gait with simultaneous movement of the hind legs or "bunny hop".

Imerslund-Gräsbeck syndrome is characterised by malabsorption of vitamin B12 (cobalamin). The first symptoms appear around 6 to 12 weeks. The clinical signs are due to the lack of cobalamin which causes megaloblastic anaemia and neurological symptoms.

Neuronal ceroid lipofuscinosis is a genetic defect characterised by a visual deficit that progresses to complete blindness, as well as progressive anxiety, cognitive and motor degeneration and lack of coordination.