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Progressive retinal atrophy (PRA1) is a genetic disease characterised by the degeneration of rod photoreceptors in the eye. The first symptoms of vision loss appear between the ages of 4 and 6.

The locus D or dilution refers to a mutation in the MLPH gene that causes a diluted coat colour. This mutation dilutes black to blue, chocolate to lilac and yellow to champagne. The mutation tested is the d^1 mutation. For the breeds Chow Chow, Sloughi and Thai Ridgeback, the test to be performed is the DOG-LOCUS-D-CHOW test.

Le poil long est causé par des mutations du gène du facteur de croissance des fibroblastes-5 (FGF5). Jusqu'à présent, cinq mutations ont été identifiées. Le test du poils long chez l'akita identifie la mutation c.578C>T qui est présente chez les races Akita, Eurasier, Samoyed et Siberian Husky. L'allèle du poil court (L) est dominant sur le poil long (l), donc deux copies de l'allèle du poil long sont nécessaires pour avoir des chiens à poil long.

PRA associated with the BBS2 gene is a hereditary form of progressive retinal degeneration characterized by damage to photoreceptor cells, leading to gradual vision loss. This progressive condition typically begins with reduced night vision and advances to complete blindness, with a variable rate of progression between individuals. Ophthalmoscopic examination reveals typical signs of bilateral retinal degeneration, including retinal thinning and vascular changes. In advanced stages, secondary complications such as cataracts may develop.

Progressive retinal atrophy (IFT122) is a genetic disease of the Finnish Lapphund that causes gradual degeneration of the retina, primarily affecting night vision. Early signs include night blindness and diffuse tapetal hyperreflectivity, detectable through an ophthalmologic examination. The disease generally progresses slowly, and some dogs may retain partial vision at an advanced age.

This test is also recommended for the Finnish Lapphund as part of the breeding program implemented by the Flemish government (see official program).

In the Giant Schnauzer, a specific form of progressive retinal atrophy (PRA) is associated with a mutation in the NECAP1 gene. The first symptoms typically appear around the age of 4. This disease is characterized by progressive retinal degeneration leading to blindness.

This test is also mandatory for Dachshunds and Pomeranians as part of the Flemish government's breeding program (see the official program).

Progressive retinal atrophy (PRA) linked to the AIPL1 gene is a hereditary genetic disease described in Persian cats. It causes rapid degeneration of retinal photoreceptors, with the onset of cell loss as early as 5 weeks of age and severe involvement by 16 weeks. The first clinical signs include an early decrease in night vision, followed by loss of daytime vision.

This test is also recommended for the Exotic Shorthair as part of the Flemish government breeding program (see the official program).

Progressive Retinal Atrophy (PRA) is a genetic disease observed in dogs, particularly in the Swedish Vallhund breed. This disease is characterized by the multifocal appearance of red and brown discoloration in the ocular fundus, followed over time by thinning of the retina. It progresses in three stages: in Stage 2, there is a gradual loss of function of both rod and cone photoreceptors, measured by electroretinography. Night blindness occurs first at the end of Stage 2, followed by decreased daytime vision in Stage 3. Histological examinations confirm the loss of photoreceptor cells at Stage 3.

This test is also recommended for the Chinese Crested Dog as part of the breeding program established by the Flemish government (see official program).

Progressive retinal atrophy causes blindness due to the destruction of the rods. The loss of vision begins at 7 weeks of age and gradually declines until it is almost complete by the age of 2 years.

This test is also recommended for the breeds Australian Mist (see the official program), Javanese (see the official program), Scottish Straight (see the official program), Thaï (see the official program), Tibetan (see the official program) as part of the Flemish government breeding program.