Search results for: 'DOG-PRA-PRCD'

Neurodegenerative vacuolar storage disease, also known as cerebellar ataxia, is a genetic disorder caused by the accumulation of non-eliminated substances in the lysosomes of nerve cells.

Affected dogs show symptoms such as progressive loss of movement coordination (ataxia), abnormal eye movements, and behavioral disorders (agitation, depression, aggression). Although reflexes may appear normal, neurological examinations often reveal atrophy of the cerebellum.

The disease is autosomal recessive, meaning that only dogs carrying two copies of the mutated gene show symptoms, usually around 23 months of age, but onset can vary.

Stargardt disease 1 is a genetic retinal disorder observed in the Labrador Retriever. It causes progressive degeneration of photoreceptors, initially affecting the visual streak and later the entire retina. Affected dogs show reduced vision, noticeable in both daylight and low-light conditions, with abnormal pupillary reflexes. The progression is slow, and most dogs retain some vision throughout their lives. Heterozygous carriers may show mild retinal abnormalities without obvious visual impairment.

This test is also recommended for the German Shorthaired Pointer as part of the breeding program of the Flemish government (see the official program).

Persistent Müllerian duct syndrome is an XY disorder of sexual development described in dogs, particularly in Miniature Schnauzers, and is associated with variants in the AMHR2 gene. Affected males generally have normal male external genitalia but retain structures derived from the Müllerian ducts, such as a uterus. Around half of affected dogs are cryptorchid, with a risk of complications such as Sertoli cell tumours or pyometra. Genetic testing is recommended before breeding, as affected males with descended testes may be fertile and carriers show no clinical signs.

Each dog has its own DNA signature. It is a sort of genetic identity card containing 22 microsatellites recommended by the International Society for Animal Genetics (ISAG). Progenus is accredited ISO17025 for this test.

Achromatopsia, also known as Early Cone Degeneration, causes daytime blindness due to degeneration of the retinal cones. It can be diagnosed in the first few weeks of a puppy's life. Affected dogs become colour blind and photophobic.

Achromatopsia, also known as Early Cone Degeneration, causes daytime blindness due to degeneration of the retinal cones. It can be diagnosed in the first few weeks of a puppy's life. Affected dogs become colour blind and photophobic.

Achromatopsia, also known as Early Cone Degeneration, causes daytime blindness due to degeneration of the retinal cones. It can be diagnosed in the first few weeks of a puppy's life. Affected dogs become colour blind and photophobic.

Increased susceptibility to Mycobacterium avium complex infection is a hereditary immunodeficiency described in Miniature Schnauzers. Associated with a variant in the CARD9 gene and inherited as an autosomal recessive trait, it predisposes homozygous dogs to progressive systemic infections. Reported signs mainly include enlarged lymph nodes, as well as anorexia, lethargy, diarrhoea and fever. In the available study, age at diagnosis ranged from 1.5 to 8 years, with a median of 2.5 years; screening for the CARD9 variant is recommended in the breed to help reduce the birth of dogs at risk.

This condition is caused by a disorder of fatty acid metabolism that reduces energy production in the muscles. Affected dogs show muscle weakness on exertion which can lead to tetraplegia, muscle pain and brownish urine after exercise.

Cystinuria is a disorder that interferes with the proper reabsorption of cystine (an amino acid) in the kidneys leading to the formation of cystine crystals in the urine. Affected dogs have cystine crystals in the kidneys and/or bladder.