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The Merle gene creates patches of colour in the coat and blue or odd-coloured eyes. Merle dogs may have hearing and eye problems. Dogs homozygous for Merle, also known as double Merle, are predominantly white and prone to several health problems. Merle can be tested in any breed, but is most often found in the breeds listed below.

Hyperuricemia, also known as hyperuricosuria, is a genetic defect causing high levels of uric acid in the urine. The clinical signs of the disease are stones in the bladder or kidneys. HUU can be tested for in any breed, but is most commonly found in the breeds listed below.

In domestic cats, the most common blood groups are A and B, while a third rare blood group, AB, is also recognized. This terminology can be confusing because type AB is not the result of a combination of groups A and B.

In Ragdoll cats, three genetic mutations allow determination of the blood group as well as the cat’s status regarding the b allele. This test is particularly important due to the risk of neonatal isoerythrolysis: the colostrum of a mother with blood group B can be fatal to a kitten with blood group A or AB.

This test analyzes mutations specific to the Ragdoll breed and is not applicable to other breeds.

Intervertebral disc disease is a premature abnormal degeneration of the intervertebral discs. In chondrodystrophic breeds, premature calcification of the nucleus pulposus causes disc degeneration in young dogs. These abnormal discs are prone to herniation into the spinal canal where inflammation and bleeding can cause severe pain and neurological dysfunction called intervertebral disc disease. This condition can lead to the death of the animal. IVDD can be tested for in any breed, but is most commonly found in the breeds listed below.