Search results for: 'DOG-CUR'

The E locus or extension refers to a mutation in the MC1R gene. For this test code, the mutation being tested is the e^2 mutation. In the Australian Cattle Dog, dogs with two copies of the e^1 or e^2 alleles or one copy of each allele will have a cream coat. For the e^1 allele and other breeds, see the following link: DOG-LOCUS-E.

This panel includes the specific tests to be performed for the Romagnol Water Dog: Benign familial juvenile epilepsy (DOG-BFJE), Progressive rod-cone degeneration (DOG-PRA-PRCD), Hyperuricosuria (DOG-HUU) and Neurodegenerative vacuolar storage disease (DOG-LSD).

The curly coat is caused by a mutation in the Keratin-71 (KRT71) gene. The test can be performed for any breed but is particularly relevant for the following breeds: Airedale Terrier, Bichon Frise, Havanese, Maltese, Border Collie, Chesapeake Bay Retriever, Chihuahua, Dachshund, Leonberger, Portuguese Water Dog, Welsh Terrier, Wire Fox Terrier. This test is not valid for the Golden Retriever.

Postoperative hemorrhage is a genetic disorder affecting platelet function. Symptoms are related to abnormal coagulation and include heavy bleeding during surgery or trauma. The first clinical signs may appear as early as birth.

Mutated dogs are naked except for the tips of the legs, the tail and the top of the head. Some dogs have very abnormal teeth, many of which are missing. In the Chinese Crested Dog, mating hairless individuals can lead to a reduction in litter size, as the presence of a double dose of the mutation in homozygous puppies results in prenatal mortality.

Cystinuria is a disorder that interferes with the proper reabsorption of cystine (an amino acid) in the kidneys leading to the formation of cystine crystals in the urine. Affected dogs have cystine crystals in the kidneys and/or bladder. 

Progressive Retinal Atrophy (PRA) is a genetic disease observed in dogs, particularly in the Swedish Vallhund breed. This disease is characterized by the multifocal appearance of red and brown discoloration in the ocular fundus, followed over time by thinning of the retina. It progresses in three stages: in Stage 2, there is a gradual loss of function of both rod and cone photoreceptors, measured by electroretinography. Night blindness occurs first at the end of Stage 2, followed by decreased daytime vision in Stage 3. Histological examinations confirm the loss of photoreceptor cells at Stage 3.

This test is also recommended for the Chinese Crested Dog as part of the breeding program established by the Flemish government (see official program).

Gangliosidosis is a genetic defect that causes the storage of GM1 gangliosides in various tissues. The clinical signs of the disease are progressive neurological dysfunction and growth retardation

Neuronal ceroid lipofuscinosis is a hereditary neurodegenerative disease, with the first symptoms typically appearing around the age of 6. It manifests as cognitive disorders, anxiety, seizures, loss of coordination, sensory impairments, and behavioral changes. Dogs affected by this condition are generally euthanized.

This test is also recommended for the Jack Russell Terrier as part of the breeding program established by the Flemish government (see official program).

Degenerative myelopathy is a neurodegenerative disease that progresses slowly and has a late onset (8 years or more). The initial clinical sign is characterised by hind limb ataxia. As the disease progresses, the frequently observed asymmetric weakness rises to affect the thoracic limbs, leading to paraplegia.