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Feline hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy. Symptoms are variable from individual to individual and include heart failure, fatigability and in some cases death of the animal. The causative mutation is different between breeds. HCM3 is specific for the Ragdoll.

This test is also recommended for the Ragamuffin as part of the Flemish government breeding program (see the official program).

Mucopolysaccharidosis VI is a lysosomal storage disease, the symptoms of which can appear as early as 6 weeks of age. These include facial dysmorphia, reduced flexibility, growth retardation, loss of mobility of posterior limbs, joint problems and corneal opacification.

In donkeys, dominant white corresponds to complete depigmentation: the animal is born with a white coat, pink skin and dark eyes. A variant in the KIT gene, c.662A>C, was identified in a donkey showing this phenotype and is considered a candidate variant associated with dominant white. The genetic test can be used to detect this variant and identify animals that carry it. However, the available data remain preliminary, as this variant was observed in only one white donkey in the study.

Ichthyosis type 2 is a skin condition caused by keratin dysfunction. The skin of affected dogs is dry, thick, scaly with large skin scales. 

In addition to the genetic test available for this form, a specific test is also available for ichthyosis type 1.

Polyneuropathy type 1 (LNP21) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Polyneuropathy type 1 (LNP1) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

This panel includes the specific tests to be performed in Ragdoll: hypertrophic cardiomyopathy type 3 (CAT-HCM3) and polycystic kidney disease (CAT-PKD)

Landseers with Ullrich-type muscular dystrophy show general muscle weakness. The first symptoms appear in the first months of life, and these dogs are euthanised or die before the age of two.

Cystinuria is a disorder that interferes with the proper reabsorption of cystine (an amino acid) in the kidneys leading to the formation of cystine crystals in the urine. Affected dogs have cystine crystals in the kidneys and/or bladder. 

Cystinuria is caused by a lack of renal reabsorption of the amino acid cystine. This excess of urinary cystine causes crystals to form, which can lead to the formation of stones in the kidney and/or bladder. Cats with cystinuria suffer from repeated inflammation of the urinary tract.