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Hypocatalasia (or acatalasemia) is a rare genetic disorder caused by a mutation in the CAT gene, leading to a severe deficiency of catalase. This enzyme normally protects tissues against oxidative stress. The c.979G>A (p.Ala327Thr) mutation was first identified in a Beagle colony and subsequently detected in pet Beagles. A homozygous dog notably developed oral cavity gangrene with tooth loss at a young age. The disease may remain clinically silent for a long time, which highlights the importance of genetic screening in breeding dogs.
This test is also recommended for the Basset Hound as part of the Flemish government breeding program (see the official program).

This panel includes the specific tests to be performed in Ragdoll: hypertrophic cardiomyopathy type 3 (CAT-HCM3) and polycystic kidney disease (CAT-PKD)

This panel includes the specific tests to be performed for the English Bulldog: canine multifocal retinopathy 1 (DOG-CMR1), hyperuricemia (DOG-HUU) and intervertebral disc disease (DOG-IVDD).

Feline hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy. Symptoms are variable from individual to individual and include heart failure, fatigability and in some cases death of the animal. The causative mutation is different between breeds. HCM3 is specific for the Ragdoll.

This package includes the mandatory tests defined by the Flemish breeding program for English Bulldog: multifocal retinopathy type 1 (DOG-CMR1) en degenerative myelopathy type 2 (DOG-DM2).

The Flemish breeding program also recommends the tests included in our DOG-BULLUK-VL+ pack.

This pack includes the recommended tests defined by the Flemish breeding program for English Bulldog: progressive retinal atrophy 4 (DOG-PRA-CRD4) and factor VII deficiency (DOG-F7).

The Flemish breeding program also requires the tests included in our DOG-BULLUK-VL pack.

Mucopolysaccharidosis VI is a lysosomal storage disease, the symptoms of which can appear as early as 6 weeks of age. These include facial dysmorphia, reduced flexibility, growth retardation, loss of mobility of posterior limbs, joint problems and corneal opacification.

Polycystic Kidney Disease (PKD) is an inherited disease that causes kidney cysts to form, leading to kidney failure. PKD cysts often present before the age of 1 year, while kidney failure usually occurs later.

Multidrug Resistance 1 is a genetic mutation in a protein that transports drugs out of the brain. This mutation causes sensitivity to certain drugs, including ivermectin and loperamide. Because of this lack of drug clearance from the brain, affected cats experience neurological symptoms such as ataxia or even death. The MDR1 mutation has currently been identified in the breeds listed below; however, the test can be conducted in any breed.

Multifocal retinopathy is an eye disease with symptoms appearing between 11 and 16 weeks of age. Affected dogs have multiple circular areas of retinal detachment. Fluid accumulates under the detached retina, resulting in blistering of the eye. The disease progresses slowly and does not usually lead to blindness.