Horse

This panel includes the specific tests to be performed in Arabians: cerebellar abiotrophy (HORSE-CA), lavender foal syndrome (HORSE-LFS), occipitoatlantoaxial malformation (HORSE-OAAM) and severe combined immunodeficiency (HORSE-SCID).

This panel includes two of the specific tests to be performed in Arabians: cerebellar abiotrophy (HORSE-CA) and severe combined immunodeficiency (HORSE-SCID).

Each horse has its own DNA signature. It is a sort of genetic identity card that includes the 17 microsatellites recommended by the International Society for Animal Genetics (ISAG). Progenus is ISO17025 accredited for this test.

Cerebellar abiotrophy is a genetic neurological disease whose main symptoms are ataxia and tremors of the legs and head. The severity of the symptoms can vary from one individual to another.

The severe combined immunodeficiency leads to a reduction in the number of B and T cells, which reduces the immune defence. SCID foals are normal at birth but are more prone to infection and quickly show signs such as high temperature, respiratory stress and diarrhoea. Affected foals do not survive beyond six months.

Fragile Foal Syndrome Type 1 (WFFS) is due to an abnormality in collagen synthesis characterised by hyperextensible, abnormally thin and fragile skin and mucous membranes that cause extensive lesions throughout the body. Signs of the disease are present from birth. Newborn foals are euthanised due to a poor prognosis for an incurable disease. The WFFS test is a patented test in Germany, France and the UK. For customers residing in these countries, please contact us.

Glycogen branching enzyme deficiency (GBED) is a disease affecting the storage of glycogen (sugar) in tissues. The disease is fatal because the brain, heart and muscles are unable to function properly. Affected animals may be stillborn, and foals that survive to term are usually euthanised.

Hereditary equine regional dermal asthenia is a genetic skin disease characterised by hyperextensible skin scars and severe lesions along the back of affected horses. Affected horses are usually euthanised.

Polysaccharide storage myopathy is a glycogen storage disease that accumulates in the muscle causing muscle damage. The symptoms of PSSM1 are muscle weakness, muscle atrophy, acute rhabdomyolysis and a reluctance of the horse to move. This test is patented and subcontracted to the patent holding laboratory.

Hyperkalaemic periodic paralysis (HYPP) is an inherited muscular disease causing muscle tremors and spasms that can be reminiscent of intermittent cramps and colic. Attacks may also be accompanied by respiratory noises resulting from paralysis of the upper airway muscles. This condition may result in sudden death of the animal.