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Skeletal dysplasia type 3 is an inherited condition described notably in the Vizsla, associated with a variant in the PCYT1A gene. It primarily results in reduced shoulder height in homozygous dogs, with notable individual variability. The skeletal abnormalities mainly affect the limbs, with shortened, thickened, and deformed bones visible on imaging. Despite these structural changes, affected dogs do not consistently show obvious clinical signs in the short term. However, long-term monitoring is recommended to assess potential orthopedic consequences with age.

Narcolepsy is a genetic disorder caused by a mutation in the orexin receptor. Affected dogs are sleepy and cannot stay awake for long periods. The first signs appear between 4 weeks and 6 months. Narcolepsy is not life-threatening.

Feline hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy. Symptoms are variable from individual to individual and include heart failure, fatigability and in some cases death of the animal. The causative mutation is different between breeds. HCM3 is specific for the Ragdoll.

This test is also recommended for the Ragamuffin as part of the Flemish government breeding program (see the official program).

Von Willebrand disease is a condition that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. 

Von Willebrand disease is a condition that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. 

Hypocatalasia (or acatalasemia) is a rare genetic disorder caused by a mutation in the CAT gene, leading to a severe deficiency of catalase. This enzyme normally protects tissues against oxidative stress. The c.979G>A (p.Ala327Thr) mutation was first identified in a Beagle colony and subsequently detected in pet Beagles. A homozygous dog notably developed oral cavity gangrene with tooth loss at a young age. The disease may remain clinically silent for a long time, which highlights the importance of genetic screening in breeding dogs.
This test is also recommended for the Basset Hound as part of the Flemish government breeding program (see the official program).

Rod-cone dysplasia type 3 is one of the various forms of progressive retinal atrophy (PRA). This mutation leads to a progressive loss of night vision and subsequently daytime vision until total blindness.

The E locus or extension refers to a mutation in the MC1R gene. For this test code, the mutation tested is the e^3 mutation. In the husky, dogs with two copies of the e^1 or e^3 alleles will have a white coat. For the e^1 allele and other breeds, see the following link:  DOG-LOCUS-E.

Multifocal CMR3 retinopathy is a genetic disease that causes multiple tears and detachments of the retina. In mild cases, the dog often shows no vision problems despite the abnormal appearance of the retina.

Laryngeal paralysis and polyneuropathy (LPPN3) is a disease characterised by breathing difficulties, often described as noisy or hoarse breathing. Other clinical signs, which vary from dog to dog, include difficulty swallowing, changes in frequency and quality of barking, high gait, lack of muscle coordination, exercise intolerance and muscle atrophy of the limbs.