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The A locus or agouti gene affects the colour of the dog's coat. There are 4 variants of the A locus: Ay (tan or sand), Aw (wolf grey or wolf sand), at (black and tan) and a (black recessive). The colour of the dog's coat is the result of the interaction of different genes including the A, B, E and K loci.

This package includes the mandatory tests defined by the Flemish breeding program for American Staffordshire Terrier: degenerative myelopathy type 2 (DOG-DM2), neuronal ceroid lipofuscinosis 4A (DOG-NCLA), progressive retinal atrophy type 4 (DOG-PRA-CRD4) and progressive retinal atrophy type 1 (DOG-PRA-RCD1).

The Flemish breeding program also recommends the tests included in our DOG-AMSTAFF-VL+ pack.

Multiple system degeneration usually begins between 9 weeks and 6 months of age. The first signs include mild tremors and stiffness of the forelimbs.
Within 3 to 4 months, symptoms worsen, with severe ataxia, spasticity, an unsteady gait, and delayed postural reactions. The disease progresses to immobility and inability to stand, often leading to euthanasia between 1 and 2 years of age.

This package includes the mandatory tests defined by the Flemish breeding program for English Springer Spaniel: Acral Mutilation Syndrome (DOG-AMS), Progressive retinal atrophy 4 (CORD1) (DOG-PRA-CRD4), Degenerative myelopathy 2 (DOG-DM2), la déficience en phosphofructokinase (DOG-PFKM) and Paradoxical pseudomyotonia (SLC7A10) (DOG-PPM). The Flemish breeding program also recommends the tests included in our package DOG-ESS-VL+.

GM2 gangliosidosis is an inherited disease caused by a deficiency of the enzyme β-hexosaminidase, leading to the accumulation of GM2 gangliosides in the nervous system.
In Korat cats, the first signs appear as early as 4 to 6 weeks of age with fine head tremors.
The disease progresses quickly with coordination problems, falls, and abnormal gait.
Affected kittens show severe deterioration over the following months.
Sadly, the outcome is fatal before 8 months of age.

 

Hereditary hyperkeratosis of the foot pads usually appears in dogs at 4–5 months of age and affects all foot pads. Over time, horny growths develop along the edges, and the pad surface becomes hard and cracked. Affected dogs tend to avoid uneven surfaces and may show lameness.

This test is also recommended for the Welsh Terrier as part of the Flemish government’s breeding program (see the official program).

In the Giant Schnauzer, a specific form of progressive retinal atrophy (PRA) is associated with a mutation in the NECAP1 gene. The first symptoms typically appear around the age of 4. This disease is characterized by progressive retinal degeneration leading to blindness.

This test is also mandatory for Dachshunds and Pomeranians as part of the Flemish government's breeding program (see the official program).

This package includes the mandatory tests defined by the Flemish breeding program for Miniature American Shepherd: Collie eye anomaly (DOG-CEA), Cataract (DOG-HSF4-BA), Multidrug Resistance 1 (DOG-MDR1), Degenerative myelopathy 2 (DOG-DM2), Coat color merle (DOG-LOCUS-M), Progressive rod-cone degeneration (DOG-PRA-PRCD), Progressive retinal atrophy (DOG-PRA-BBS2), Neuroaxonal dystrophy (DOG-NAD-MAS) and Progressive retinal atrophy 4 (CORD1) (DOG-PRA-CRD4). The Flemish breeding program also recommends the tests included in our package DOG-BGAM-VL+.

Neuro-axonal dystrophy (NAD) in Papillon dogs is a rare inherited neurological disorder that causes progressive degeneration of the central nervous system.
Signs appear very early, usually between 2 and 4 months of age, and include gait abnormalities, head and limb tremors, weakness of the hind limbs, and in some cases, involvement of the forelimbs or visual deficits.
The progression is rapid and severe: affected dogs may have difficulty eating and are often euthanized shortly after the onset of symptoms due to a reserved vital prognosis.

RAB24-related cerebellar cortical abiotrophy is an autosomal recessive hereditary disorder described in the Old English Sheepdog and the Gordon Setter. The first signs appear between 6 months and 4 years of age, with progressive cerebellar ataxia, marked hypermetria, truncal sway and intention tremors, which may progress to severe gait disturbances. MRI can reveal cerebellar atrophy, and the reported lesions notably include a marked loss of Purkinje neurons. The genetic test allows identification of the associated RAB24 variant; it is also recommended in the Flemish Region breeding programme for the Airedale Terrier.