Search results for: 'DOG-PRA-PRCD'

The A locus or agouti gene affects the colour of the dog's coat. There are 4 variants of the A locus: Ay (tan or sand), Aw (wolf grey or wolf sand), at (black and tan) and a (black recessive). The colour of the dog's coat is the result of the interaction of different genes including the A, B, E and K loci.

Amelogenesis imperfecta (AI) is a genetic disorder affecting tooth enamel, causing it to be thin, brittle, or poorly mineralized. In Akitas, a recessive variant in the ACP4 gene has been identified, leading to hypoplastic AI due to an abnormal protein structure. The carrier frequency in Akitas is 22%. While AI cannot be cured, genetic testing can help manage breeding programs and improve dental care strategies.

Van den Ende-Gupta syndrome is a congenital skeletal development disorder affecting Wire Fox Terriers. It is characterized notably by severe mandibular prognathism (forward lower jaw) and low bone mineralization. Affected animals frequently present with luxations, particularly of the patella and elbow.

This test is also recommended for the Welsh Terrier as part of the breeding program of the Flemish government (see the official program).

Lethal acrodermatitis is a genetic disease of the immune system. The clinical signs are skin lesions on the paws and muzzle, leading to secondary infections. In addition, the lesions cause hyperkeratosis of the pads and deformation of the nails. Affected puppies also suffer from diarrhea, bronchopneumonia and retarded growth. The first symptoms appear quickly after birth. Affected puppies usually die before 2 years of age or are euthanized.

Juvenile laryngeal paralysis and polyneuropathy also known as polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV) is a neurological defect seen in Black Russian Terriers and Rottweilers where the disease is known as neuronal vacuolation and neuronal vacuolation and spinocerebellar degeneration (NVSD). Signs of disease include early onset of laryngeal paralysis, microphthalmia (small eyes), cataract and muscle weakness. The disease is progressive and affected animals die or are euthanised

Malignant hyperthermia, also known as canine stress syndrome, is a potentially fatal genetic disorder. The clinical signs of malignant hyperthermia are extreme muscle contractions, increased heart rate and fever. These symptoms are triggered by certain anaesthetics such as halothane, but also by intense exercise and certain foods. Malignant hyperthermia can be tested for in any breed, but is most commonly found in the breeds listed below.

Hereditary nasal parakeratosis is a genetic disease in Greyhounds that affects corneogenesis, causing abnormal thickening of the stratum corneum of the nose’s epidermis. The main symptoms include a thickened, dry, and rough nose, often covered with crusts and showing cracks. The condition can cause local discomfort and, in some cases, pain if the cracks are deep.

This test is also recommended for Salukis as part of the breeding program implemented by the Flemish government (see official program).

Le poil long est causé par des mutations du gène du facteur de croissance des fibroblastes-5 (FGF5). Jusqu'à présent, cinq mutations ont été identifiées. Le test du poils long chez l'akita identifie la mutation c.578C>T qui est présente chez les races Akita, Eurasier, Samoyed et Siberian Husky. L'allèle du poil court (L) est dominant sur le poil long (l), donc deux copies de l'allèle du poil long sont nécessaires pour avoir des chiens à poil long.

Degenerative myelopathy is a neurodegenerative disease that progresses slowly and has a late onset (8 years or more). The initial clinical sign is characterised by hind limb ataxia. As the disease progresses, the frequently observed asymmetric weakness rises to affect the thoracic limbs, resulting in paraplegia. The majority of DM2/DM2 animals will not develop symptoms, however, elimination of these animals from breeding patterns reduces the genetic variability of the breed, which is why Progenus does not recommend this test.

The microphthalmia in Soft-Coated Wheaten Terriers is a congenital ocular malformation associated with a mutation (K12del) in the RBP4 gene, which disrupts the transport of vitamin A essential for eye development. The disease follows a particular inheritance pattern dependent on a maternal effect, where the genotype of the mother directly influences embryonic development. It results in an abnormally reduced development of one or both eyes in the puppy.

This test is also mandatory for the Jack Russell Terrier as part of the Flemish government's official breeding program (see official program).