Search results for: 'DOG-PRA-PRCD'

Van den Ende-Gupta syndrome is a congenital skeletal development disorder affecting Wire Fox Terriers. It is characterized notably by severe mandibular prognathism (forward lower jaw) and low bone mineralization. Affected animals frequently present with luxations, particularly of the patella and elbow.

This test is also recommended for the Welsh Terrier as part of the breeding program of the Flemish government (see the official program).

Degenerative myelopathy is a neurodegenerative disease that progresses slowly and has a late onset (8 years or more). The initial clinical sign is characterised by hind limb ataxia. As the disease progresses, the frequently observed asymmetric weakness rises to affect the thoracic limbs, resulting in paraplegia. The majority of DM2/DM2 animals will not develop symptoms, however, elimination of these animals from breeding patterns reduces the genetic variability of the breed, which is why Progenus does not recommend this test.

Le poil long est causé par des mutations du gène du facteur de croissance des fibroblastes-5 (FGF5). Jusqu'à présent, cinq mutations ont été identifiées. Le test du poils long chez l'akita identifie la mutation c.578C>T qui est présente chez les races Akita, Eurasier, Samoyed et Siberian Husky. L'allèle du poil court (L) est dominant sur le poil long (l), donc deux copies de l'allèle du poil long sont nécessaires pour avoir des chiens à poil long.

Malignant hyperthermia, also known as canine stress syndrome, is a potentially fatal genetic disorder. The clinical signs of malignant hyperthermia are extreme muscle contractions, increased heart rate and fever. These symptoms are triggered by certain anaesthetics such as halothane, but also by intense exercise and certain foods. Malignant hyperthermia can be tested for in any breed, but is most commonly found in the breeds listed below.

Hereditary nasal parakeratosis is a genetic disease in Greyhounds that affects corneogenesis, causing abnormal thickening of the stratum corneum of the nose’s epidermis. The main symptoms include a thickened, dry, and rough nose, often covered with crusts and showing cracks. The condition can cause local discomfort and, in some cases, pain if the cracks are deep.

This test is also recommended for Salukis as part of the breeding program implemented by the Flemish government (see official program).

The microphthalmia in Soft-Coated Wheaten Terriers is a congenital ocular malformation associated with a mutation (K12del) in the RBP4 gene, which disrupts the transport of vitamin A essential for eye development. The disease follows a particular inheritance pattern dependent on a maternal effect, where the genotype of the mother directly influences embryonic development. It results in an abnormally reduced development of one or both eyes in the puppy.

This test is also mandatory for the Jack Russell Terrier as part of the Flemish government's official breeding program (see official program).

Cerebellar hypoplasia in the White Swiss Shepherd is a genetic disease linked to an abnormality in the development of the cerebellum. Symptoms generally appear between 2 and 4 weeks of age and include progressive ataxia (loss of co-ordination of movement), difficulty standing upright, walking in a straight line and difficulty suckling. Affected puppies show a normal sucking reflex, but have difficulty attaching to the nipple. At necropsy, severe anatomical abnormalities are observed, including the absence of cerebellar folia, moderate internal hydrocephalus and alterations in the structure of the cerebellum, with disorganised cell layers. The disease generally leads to the euthanasia of puppies at around 4 weeks of age.

Osteochondrodysplasia is a skeletal developmental disorder that appears very early in puppies. It causes visible bone deformities, such as shortened or curved limbs, enlarged joints, a flattened rib cage, and sometimes a shortened lower jaw. Radiographs reveal abnormalities in ossification, particularly in the epiphyses and vertebrae. Affected puppies show marked joint stiffness that decreases with age, but mobility remains limited. In the long term, osteoarthritis is common and has a lasting impact on quality of life.

This test is also recommended for the Papillon as part of the Flemish government breeding program (see the official program).

Congenital myasthenic syndrome is an inherited neuromuscular disease observed in the Jack Russell Terrier. Affected puppies appear normal until 6 weeks of age, then gradually develop generalized muscle weakness, walking briefly for 10 to 15 steps before stopping or lying down. Treatment with anticholinesterase drugs leads to temporary improvement, but resistance to the treatment often requires euthanasia.

In the Jack Russell Terrier, congenital myasthenia is most commonly caused by the 729dup mutation. However, under the breeding regulation of the Flemish government, it is the 1508dup mutation that must be tested for in both the Jack Russell Terrier and the American Staffordshire Terrier. This test specifically detects the 1508dup mutation.