Search results for: 'DOG-PRA-PRCD'

Imerslund-Gräsbeck syndrome is characterised by malabsorption of vitamin B12 (cobalamin). The first symptoms appear around 6 to 12 weeks. The clinical signs are due to the lack of cobalamin which causes megaloblastic anaemia and neurological symptoms.

Neuronal ceroid lipofuscinosis is a genetic defect characterised by a visual deficit that progresses to complete blindness, as well as progressive anxiety, cognitive and motor degeneration and lack of coordination.

Polyneuropathy type 1 (LNP1) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Progressive retinal atrophy is an inherited eye disease characterized by bilateral degeneration of the photoreceptor cells of the retina resulting in progressive vision loss leading to total blindness. Other mutations can cause progressive retinal atrophy. 

Footpad hyperkeratosis is a genetic disease causing a proliferation of epidermal cells. The symptoms of this pathology are thickening and hardening of the pads of all four paws. The first clinical signs usually appear during the first year of life.

Mitochondrial fission encephalopathy is a genetic disease of the nervous system. Bullmastiffs with MFE show a variety of symptoms such as ataxia, visual impairment, progressive gait abnormalities and behavioral abnormalities. The first clinical signs are usually observed around 6 months of age.

Puppies with dry eye/curly coat syndrome have keratoconjunctivitis sicca in the eyes, a curly coat, and are generally smaller than their peers. The footpads are hyperkeratinised with abnormal claw growth.

L'insuffisance d'Adhérence Leucocytaire est une anomalie du système immunitaire. En raison de la mutation, les leucocytes ne détruisent pas les bactéries et les virus conduisant à la mort des chiots atteints.

This cardiomyopathy leads to death without apparent cause at around 6-8 weeks of age in the Belgian Shepherd. Symptoms of this condition vary from individual to individual and include: vomiting, dyspnoea, enlarged heart, difficulty in locomotion, tremors.

Miniature schnauzer polyneuropathy is a genetic neuromuscular disorder. Symptoms may include exercise intolerance, muscle atrophy mainly in the hind legs, laryngeal paralysis resulting in a change in barking and noisy breathing. The first signs of the disease usually appear around 3 months of age.