Search results for: 'DOG-PRA-PRCD'

In puppies with CHG, thyroid function is reduced. The main symptoms are enlarged thyroid glands, goiter and growth retardation. The first clinical signs appear a few weeks after birth.

Leukocyte Adhesion Deficiency is an abnormality of the immune system. Due to the mutation, the leukocytes do not destroy bacteria and viruses leading to the death of affected puppies.

Neural ceroid-lipofuscinosis is a genetic defect characterised by progressive behavioural changes, hyperactivity, dementia, aggression, loss of coordination, ataxia, delayed postural responses, blindness and slow responses to pupillary light.

Polyneuropathy type 1 (LNP21) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

Spinal dysraphism is a genetic disease with symptoms present from birth. Affected puppies show neurological abnormalities including motor disorders in the hind legs. Adults show a typical abnormal gait with simultaneous movement of the hind legs or "bunny hop".

Myotonia congenita is a genetic disease affecting the mechanism of muscle contraction, the main symptoms of which are muscle hypertrophy, a stiff gait, difficulty swallowing and dental anomalies. Clinical signs appear within a few weeks of birth.

Exfoliative cutaneous lupus erythematosus is a genetic skin disease whose symptoms are erythema, scabbing, alopecia and scaling of the skin. The first signs of the disease usually appear during the first year.

Neonatal interstitial lung disease is a genetic disease affecting the pulmonary system and causing lethal hypoxic respiratory failure in the first weeks of life. Other symptoms include lethargy, refusal to suckle and breathing difficulties ('dyspnea' or tachypnea).

Neonatal ataxia, also known as Bandera syndrome, is caused by a genetic mutation that alters the part of the nervous system that controls coordination and movement. Symptoms of neonatal ataxia include falling and inability to walk.

Glanzmann's thrombasthenia is an inherited bleeding disorder caused by a defect in the platelet glycoprotein αIIbβ3, which is essential for platelet aggregation.
Without this functional glycoprotein, the platelet plug forms poorly, leading to excessive bleeding after trauma or surgical procedures.