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Narcolepsy is a genetic disorder caused by a mutation in the orexin receptor. Affected dogs are sleepy and cannot stay awake for long periods. The first signs appear between 4 weeks and 6 months. Narcolepsy is not life-threatening.

Neuroaxonal dystrophy is a genetic neurodegenerative disease. Symptoms include various neurological symptoms such as abnormal gait, loss of balance, head tremors and involuntary eye movements (nystagmus).

Progressive retinal atrophy (PRA1) is a genetic disease characterised by the degeneration of rod photoreceptors in the eye. The first symptoms of vision loss appear between the ages of 4 and 6.

Imerslund-Gräsbeck syndrome is characterised by malabsorption of vitamin B12 (cobalamin). The first symptoms appear around 6 to 12 weeks. The clinical signs are due to the lack of cobalamin which causes megaloblastic anaemia and neurological symptoms.

This cardiomyopathy leads to death without apparent cause at around 6-8 weeks of age in the Belgian Shepherd. Symptoms of this condition vary from individual to individual and include: vomiting, dyspnoea, enlarged heart, difficulty in locomotion, tremors.

Narcolepsy is a genetic disorder caused by a mutation in the orexin receptor. Affected dogs are sleepy and cannot stay awake for long periods. The first signs appear between 4 weeks and 6 months. Narcolepsy is not life-threatening.

Narcolepsy is a genetic disorder caused by a mutation in the orexin receptor. Affected dogs are sleepy and cannot stay awake for long periods. The first signs appear between 4 weeks and 6 months. Narcolepsy is not life-threatening.

Congenital myasthenic syndrome is caused by a malfunction in the transmission of nerve signals to the muscle, with symptoms usually appearing between 6 and 12 weeks of age. Affected puppies show generalised skeletal muscle weakness and fatigue, usually induced by exercise.

Mitochondrial fission encephalopathy is a genetic disease of the nervous system. Bullmastiffs with MFE show a variety of symptoms such as ataxia, visual impairment, progressive gait abnormalities and behavioral abnormalities. The first clinical signs are usually observed around 6 months of age.

Cerebellar degeneration—myositis complex is a degenerative encephalopathy. Clinical signs in affected dogs are highly variable and may include muscle weakness, generalized ataxia and hypermetria. The age of onset of neurological signs is between 10 weeks and 6 months.