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Juvenile laryngeal paralysis and polyneuropathy also known as polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV) is a neurological defect seen in Black Russian Terriers and Rottweilers where the disease is known as neuronal vacuolation and neuronal vacuolation and spinocerebellar degeneration (NVSD). Signs of disease include early onset of laryngeal paralysis, microphthalmia (small eyes), cataract and muscle weakness. The disease is progressive and affected animals die or are euthanised

Long hair is caused by mutations in the fibroblast growth factor-5 (FGF5) gene. To date, five mutations have been identified. The longhair test identifies the p.Cys95Phe mutation, which is the most common across breeds. The shorthair allele (L) is dominant over the longhair allele (l), so two copies of the longhair allele are required to produce longhaired dogs. The specific test for the Akita breed is available: see Longhair test - Akita (DOG-LHA)