Search results for: 'DOG-PRA-PRCD'

Neuro-axonal dystrophy (NAD) in Papillon dogs is a rare inherited neurological disorder that causes progressive degeneration of the central nervous system.
Signs appear very early, usually between 2 and 4 months of age, and include gait abnormalities, head and limb tremors, weakness of the hind limbs, and in some cases, involvement of the forelimbs or visual deficits.
The progression is rapid and severe: affected dogs may have difficulty eating and are often euthanized shortly after the onset of symptoms due to a reserved vital prognosis.

Landseers with Ullrich-type muscular dystrophy show general muscle weakness. The first symptoms appear in the first months of life, and these dogs are euthanised or die before the age of two.

Cataracts are one of the leading causes of blindness in dogs. This test highlights a mutation in the HSF4 gene that is considered a risk factor for the development of cataracts.

Multifocal CMR3 retinopathy is a genetic disease that causes multiple tears and detachments of the retina. In mild cases, the dog often shows no vision problems despite the abnormal appearance of the retina.

Long hair is caused by mutations in the fibroblast growth factor-5 (FGF5) gene. To date, five mutations have been identified. The longhair test identifies the p.Cys95Phe mutation, which is the most common across breeds. The shorthair allele (L) is dominant over the longhair allele (l), so two copies of the longhair allele are required to produce longhaired dogs. The specific test for the Akita breed is available: see Longhair test - Akita (DOG-LHA)

Multifocal CMR3 retinopathy is a genetic disease that causes multiple tears and detachments of the retina. In mild cases, the dog often shows no vision problems despite the abnormal appearance of the retina.

Each dog has its own DNA signature. It is a sort of genetic identity card containing 22 microsatellites recommended by the International Society for Animal Genetics (ISAG). Progenus is accredited ISO17025 for this test.

Neurodegenerative vacuolar storage disease, also known as cerebellar ataxia, is a genetic disorder caused by the accumulation of non-eliminated substances in the lysosomes of nerve cells.

Affected dogs show symptoms such as progressive loss of movement coordination (ataxia), abnormal eye movements, and behavioral disorders (agitation, depression, aggression). Although reflexes may appear normal, neurological examinations often reveal atrophy of the cerebellum.

The disease is autosomal recessive, meaning that only dogs carrying two copies of the mutated gene show symptoms, usually around 23 months of age, but onset can vary.

Stargardt disease 1 is a genetic retinal disorder observed in the Labrador Retriever. It causes progressive degeneration of photoreceptors, initially affecting the visual streak and later the entire retina. Affected dogs show reduced vision, noticeable in both daylight and low-light conditions, with abnormal pupillary reflexes. The progression is slow, and most dogs retain some vision throughout their lives. Heterozygous carriers may show mild retinal abnormalities without obvious visual impairment.

This test is also recommended for the German Shorthaired Pointer as part of the breeding program of the Flemish government (see the official program).

Achromatopsia, also known as Early Cone Degeneration, causes daytime blindness due to degeneration of the retinal cones. It can be diagnosed in the first few weeks of a puppy's life. Affected dogs become colour blind and photophobic.