Search results for: 'DOG-PRA-PRCD'

Dwarfism is a slowing of growth. Pituitary dwarfism in German Shepherds produces perfectly proportioned but much smaller dogs. It is caused by a dysfunction of the pituitary gland which reduces the plasma concentrations of growth and thyroid hormones. This hormonal alteration usually results in malformations of the genitalia. These dogs can lead a normal life if they receive appropriate hormonal treatment.

Spinocerebellar ataxia (LOA) is a genetic disease of the nervous system. Affected dogs present the first signs of ataxia around the age of 6 to 12 months. The symptoms of this pathology are a loss of balance, a progressive lack of coordination until the total loss of mobility. nother test for spinocerebellar ataxia is available. For more information, consult the DOG-SCA test.

The E locus or extension refers to a mutation in the MC1R gene. For this test code, the mutation tested is the e^3 mutation. In the husky, dogs with two copies of the e^1 or e^3 alleles will have a white coat. For the e^1 allele and other breeds, see the following link:  DOG-LOCUS-E.

Muscle hypertrophy in whippets, sometimes called “bully,” is a genetic trait that results in a highly developed musculature, particularly in the neck and limbs.
Affected dogs have a broad chest and generally do not conform to the breed standard, which favors a slim body, long neck, and pointed muzzle.
Whippets carrying a single copy of the mutation show moderate muscular development but are often faster than dogs homozygous for the normal allele, providing a performance advantage.

Spinocerebellar ataxia (SCA or SAMS) is a genetic disease of the nervous system. Affected dogs present the first signs of ataxia around the age of 3 to 6 months. The symptoms of this pathology are a loss of balance, a progressive lack of coordination until the total loss of mobility. Another test for late-onset spinocerebellar ataxia is available. For more information, consult the DOG-LOA test.

RHO-related progressive retinal atrophy is an inherited eye disorder described in the English Mastiff, transmitted in an autosomal dominant manner. In carrier dogs, rod-mediated vision may remain normal during the first few months, before retinal degeneration generally becomes evident between 12 and 18 months of age. The disease is also characterized by abnormally slow recovery of photoreceptor function after light exposure, with more severe signs reported in homozygous dogs.

Dogs with POAG have elevated intraocular pressure that can lead to vision loss. Symptoms of this condition include eye pain, excessive blinking and tearing.

Complement factor C3 deficiency in dogs is a condition that leads to immune system failure. This condition makes affected dogs more susceptible to multiple and recurrent bacterial infections, as well as certain kidney diseases of immune origin. The gene involved in this pathology is the C3 gene, with a specific mutation identified as c.2136delC. The frequency of carriers of this mutation is approximately 1%, and symptoms can appear from a very young age.

Dogs with POAG have elevated intraocular pressure that can lead to vision loss. Symptoms of this condition include eye pain, excessive blinking and tearing.

Thrombopathia is a genetic disease that affects platelet function. In thrombopathia, platelets are unable to stick together properly and therefore cannot clot normally. The most common symptoms of this condition are recurrent nosebleeds and excessive bleeding from the gums and bruising. Internal bleeding and black or red stools may also be observed. Although dogs with this condition are at risk for spontaneous bleeding and internal bleeding, affected dogs may not be identified until surgery is performed or trauma occurs.