Search results for: 'DOG-PRA-PRCD'

This package includes the mandatory tests defined by the Flemish breeding program for Prague Ratter: Von Willebrand disease type 1 (DOG-VWD1) and Primary lens luxation (DOG-PLL).

This package includes the mandatory tests defined by the Flemish breeding program for Fox Terrier: Degenerative myelopathy type 2 (DOG-DM2) and Van den Ende-Gupta syndrome (DOG-VDEG).

This panel includes the essential tests to be performed for New Scotland Retriever: Cleft Lip and Palate and Syndactyly (DOG-CL/P) and Cerebellar degeneration with myositis (DOG-CDMC).

Ce profil reprend les analyses spécifiques à effectuer chez le teckel: l'ostéogénèse imparfaite (DOG-OSTEO-T) et la dystrophie des cônes et des bâtonnets (DOG-CRD-SWHD).

The term furnishings describes the longer moustache and eyebrows seen in wirehaired dogs and other breeds and is due to a variant of the R-spondin-2 (RSPO2) gene. In some breeds such as the Labradoodle, Goldendoodle and Portuguese Water Dog, the lack of trimming is called improper coat. The test can be performed for any breed, but is particularly relevant for the following breeds: Briard, Havanese, Maltese, Old English Sheepdog, Bouvier Des Flandres, German Pointer, Poodle, Chinese Crested Dog, Portuguese Water Dog, Goldendoodle, Brussels Griffon, Labradoodle, Shih Tzu, Dachshund,Soft-coated Wheaten Terrier, Jack Russell Terrier, Black Russian Terrier, Yorkshire Terrier.

The B (brown) locus refers to a mutation in the TYRP1 gene causing the brown colour of the coat, also called liver or chocolate. The black (B) allele is dominant over the brown alleles (bs, bd, bc). For red or yellow dogs, the brown allele will not change the colour of the coat, but will change the colour of the nose and the pads of the paws. Other mutations can cause brown coat colour in the Australian Shepherd (DOG-LOCUS-B-BGAUST) and Lancashire Heeler (DOG-LOCUS-B-LHEELER). This test does not detect the mutation for chocolate (DOG-COCOA) in French Bulldogs.

The mutation responsible for the cocoa colour in the French bulldog has been identified in the Hermansky-Pudlak syndrome 3 (HPS3) gene. Dogs homozygous for this mutation are a shade darker brown than dogs mutated for brown (Locus B).  In humans and mice, mutations in the HPS3 gene are associated with symptoms such as visual impairment, abnormal eye pigmentation and bleeding. These effects of the mutation have not been reported in dogs homozygous for the cocoa variant. ogs with two copies of the cocoa variant can be cocoa, however the final colour of the dog also depends on other genes controlling coat colour.  

Prekallikrein (PK) deficiency in dogs is a hereditary coagulation disorder characterized by a prolonged activated partial thromboplastin time (aPTT). Most affected dogs remain asymptomatic and do not show spontaneous bleeding in the absence of other coagulation abnormalities. In rare cases, hemorrhagic signs such as gastrointestinal bleeding, hematuria, or prolonged healing time after surgery may occur.

This test is also recommended for Maltese dogs as part of the breeding program of the Flemish government (see the official program).

Skeletal Dysplasia 2 (SD2) is a genetic disorder causing mild disproportionate dwarfism. Affected dogs have short legs with normal proportions for the rest of the body. This mutation has incomplete penetrance: not all dogs with two copies of the defective gene will show signs of skeletal dysplasia.

Laryngeal paralysis and polyneuropathy (LPPN3) is a disease characterised by breathing difficulties, often described as noisy or hoarse breathing. Other clinical signs, which vary from dog to dog, include difficulty swallowing, changes in frequency and quality of barking, high gait, lack of muscle coordination, exercise intolerance and muscle atrophy of the limbs.