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In the Giant Schnauzer, a specific form of progressive retinal atrophy (PRA) is associated with a mutation in the NECAP1 gene. The first symptoms typically appear around the age of 4. This disease is characterized by progressive retinal degeneration leading to blindness.

This test is also mandatory for Dachshunds and Pomeranians as part of the Flemish government's breeding program (see the official program).

Long hair is caused by mutations in the fibroblast growth factor-5 (FGF5) gene. To date, five mutations have been identified. The longhair test identifies the p.Cys95Phe mutation, which is the most common across breeds. The shorthair allele (L) is dominant over the longhair allele (l), so two copies of the longhair allele are required to produce longhaired dogs. The specific test for the Akita breed is available: see Longhair test - Akita (DOG-LHA)

The Merle gene creates patches of colour in the coat and blue or odd-coloured eyes. Merle dogs may have hearing and eye problems. Dogs homozygous for Merle, also known as double Merle, are predominantly white and prone to several health problems. Merle can be tested in any breed, but is most often found in the breeds listed below.

Intervertebral disc disease is a premature abnormal degeneration of the intervertebral discs. In chondrodystrophic breeds, premature calcification of the nucleus pulposus causes disc degeneration in young dogs. These abnormal discs are prone to herniation into the spinal canal where inflammation and bleeding can cause severe pain and neurological dysfunction called intervertebral disc disease. This condition can lead to the death of the animal. IVDD can be tested for in any breed, but is most commonly found in the breeds listed below.