Search results for: 'DOG-PRA-PRCD'

Progressive retinal atrophy causes blindness due to the destruction of the rods. The loss of vision begins at 7 weeks of age and gradually declines until it is almost complete by the age of 2 years.

Progressive retinal atrophy 4, also known as CORD1, is a form of progressive retinal atrophy characterised by changes in the granular appearance of the fundus, followed by generalised tapetal hyperreflexia and retinal vascular attenuation with progressive extinction of the electroretinogram. CORD1 pathology is probably caused by a combination of mutations. Only the mutation in the RPGRIP1 gene is being tested.

This test is also recommended for the Miniature Poodle as part of the Flemish government breeding program

Cerebral neuronal lipofuscinosis type 8 (NCL8) is a hereditary neurodegenerative disease observed in certain breeds such as the German Shorthaired Pointer and the Australian Shepherd. Puppies develop normally until 12–14 months of age, after which signs of neurological degeneration appear, including visual impairment, repetitive behaviors, and decreased responsiveness to commands. The disease progresses to blindness, ataxia, and loss of motor function in the limbs, accompanied by frequent epileptic seizures. Due to the severity of symptoms and rapid progression, affected animals are often euthanized before 27 months of age.

Von Willebrand disease is a disease that causes excessive bleeding due to a lack or reduced level of von Willebrand factor (vWF), a blood clotting protein. This disease is inherited as a dominant trait with incomplete penetrance, which means that not all dogs carrying the vWF mutation will show clinical signs of the disease.

Multifocal retinopathy is an eye disease with symptoms appearing between 11 and 16 weeks of age. Affected dogs have multiple circular areas of retinal detachment. Fluid accumulates under the detached retina, resulting in blistering of the eye. The disease progresses slowly and does not usually lead to blindness.

Primary lens luxation is an autosomal recessive eye disease that causes inflammation and glaucoma. Lens luxation occurs between the ages of 3 and 8, with the lens moving away from its normal position ( luxation) with symptoms including red, watery eyes. If left untreated, PLL can quickly lead to blindness. The test can be performed for any breed, but is most commonly found in the breeds listed below.

The Merle gene creates patches of colour in the coat and blue or odd-coloured eyes. Merle dogs may have hearing and eye problems. Dogs homozygous for Merle, also known as double Merle, are predominantly white and prone to several health problems. Merle can be tested in any breed, but is most often found in the breeds listed below.

This panel includes the specific tests to be performed for the German Shepherd Dog: achromatopsia (DOG-ACHMB), Scott syndrome (DOG-CSS), coat length (DOG-LH), multidrug resistance (DOG-MDR1), mucopolysaccharidosis VII (DOG-MPS7), dwarfism (DOG-NAN), renal cystadenocarcinoma and nodular dermatofibrosis (DOG-RCND) and X-linked hypohidrotic ectodermal dysplasia (DOG-XHED).

Brachyury, also known as bobtail, is a dominant mutation that is lethal in utero in the homozygous state (two copies of the bobtail mutation). This test also identifies whether the dog's tail is naturally short or whether it has been docked. The list of breeds for which the test is validated is shown below. In six other breeds studied, the short tail is not due to the mutation tested: Boston Terrier, English Bulldog, King Charles Spaniel, Miniature Schnauzer, Parson Russell Terrier, Rottweiler

This panel includes the specific tests to be performed for Border Collie: hyperuricosuria  (DOG-HUU), Imerslund-Gräsbeck syndrome (DOG-IGSB), myotonia congenita (DOG-MC), Multidrug Resistance (DOG-MDR1), malignant hyperthermia (DOG-MH), neuronal ceroid lipofuscinosis type 5 (DOG-NCL5), dental hypomineralisation (DOG-RAINE) and trapped neutrophil syndrome (DOG-TNS).