Search results for: 'DOG-PRA-PRCD'

Von Willebrand disease is a condition that causes excessive bleeding due to a deficiency or reduced levels of von Willebrand factor (vWF), a blood clotting protein.

This mutation is found in the Chinese Crested dog, but homozygous dogs do not appear to show clinical signs of bleeding disorders.

Progressive retinal atrophy (PRA1) is a genetic disease characterised by the degeneration of rod photoreceptors in the eye. The first symptoms of vision loss appear between the ages of 4 and 6.

Degenerative myelopathy is a neurodegenerative disease that progresses slowly and has a late onset (8 years or more). The initial clinical sign is characterised by hind limb ataxia. As the disease progresses, the frequently observed asymmetric weakness rises to affect the thoracic limbs, leading to paraplegia.

Neuronal ceroid lipofuscinosis is a hereditary neurodegenerative disease, with the first symptoms typically appearing around the age of 6. It manifests as cognitive disorders, anxiety, seizures, loss of coordination, sensory impairments, and behavioral changes. Dogs affected by this condition are generally euthanized.

This test is also recommended for the Jack Russell Terrier as part of the breeding program established by the Flemish government (see official program).

Multiple system degeneration usually begins between 9 weeks and 6 months of age. The first signs include mild tremors and stiffness of the forelimbs.
Within 3 to 4 months, symptoms worsen, with severe ataxia, spasticity, an unsteady gait, and delayed postural reactions. The disease progresses to immobility and inability to stand, often leading to euthanasia between 1 and 2 years of age.

Neuronal ceroid lipofuscinosis is a genetic defect characterised by cognitive impairment, blindness and anxiety.

Myotonia congenita is a genetic disorder characterised by delayed skeletal muscle relaxation after contraction. The clinical signs are a stiff gait and hypertrophy of the skeletal muscles.

Multidrug Resistance 1 is a genetic mutation in a protein that transports drugs out of the brain. This mutation causes sensitivity to certain drugs, including ivermectin and loperamide. Because of this lack of drug clearance from the brain, affected dogs experience neurological symptoms such as ataxia or even death. MDR1 can be tested for in any breed, but is most commonly found in the breeds listed below.

Neuronal ceroid lipofuscinosis is a genetic defect characterised by progressive behavioural changes, hyperactivity, dementia, aggression, loss of coordination, ataxia, delayed postural responses, blindness and slow responses to pupillary light.

Progressive retinal atrophy causes blindness due to the destruction of the photoreceptors in the retina. The loss of vision begins at the age of 7 months and gradually declines until it is almost complete by the age of 3 to 5 years.