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Multiple system degeneration usually begins between 9 weeks and 6 months of age. The first signs include mild tremors and stiffness of the forelimbs.
Within 3 to 4 months, symptoms worsen, with severe ataxia, spasticity, an unsteady gait, and delayed postural reactions. The disease progresses to immobility and inability to stand, often leading to euthanasia between 1 and 2 years of age.

This package includes the mandatory tests defined by the Flemish breeding program for Australian cattle dog: Degenerative myelopathy 2 (DOG-DM2), Neuronal ceroid lipofuscinosis type 12 (DOG-NCL12-ACD), Neuronal ceroid lipofuscinosis type 5 (DOG-NCL5), Primary lens luxation (DOG-PLL), Progressive rod-cone degeneration (DOG-PRA-PRCD). The Flemish breeding program also recommends the tests included in our package DOG-AC-VL+.

This package includes the mandatory tests defined by the Flemish breeding program for English Springer Spaniel: Acral Mutilation Syndrome (DOG-AMS), Progressive retinal atrophy 4 (CORD1) (DOG-PRA-CRD4), Degenerative myelopathy 2 (DOG-DM2), la déficience en phosphofructokinase (DOG-PFKM) and Paradoxical pseudomyotonia (SLC7A10) (DOG-PPM). The Flemish breeding program also recommends the tests included in our package DOG-ESS-VL+.

Hypomyelination, also known as Shaking pup syndrome, is a disorder of the nervous system caused by a defect in the myelination of the spinal cord. Affected dogs show tremors, walking difficulties, balance and coordination problems. This disease is transmitted in an X-linked recessive manner, so males carrying the mutation will all be affected. However, only females with 2 copies of the mutated allele will be affected.

This package includes the mandatory tests defined by the Flemish breeding program for Labradoodle: Degenerative myelopathy 2 (DOG-DM2), Centronuclear myopathy (DOG-CNM), Exercise-induced collapse (DOG-EIC), Hereditary nasal parakeratosis (DOG-HNPK), Progressive rod-cone degeneration (DOG-PRA-PRCD), Stargardt disease (DOG-STGD) and Von Willebrand disease type 1 (DOG-VWD1). The Flemish breeding program also recommends the tests included in our package DOG-DOODLE-VL+.

This pack includes the recommended tests defined by the Flemish breeding program for German Shorthaired Pointer: Achromatopsia (CNGB3) (DOG-ACHM3), Acral Mutilation Syndrome (DOG-AMS), ichtyosis type 1 (DOG-ICHGR-1), Progressive rod-cone degeneration (DOG-PRA-PRCD), Stargardt disease (DOG-STGD) and Von Willebrand disease type 2 (DOG-VWD2-BA). The Flemish breeding program also makes the tests included in our package mandatory DOG-BRQALLD-VL.

The locus D or dilution refers to a mutation in the MLPH gene that causes a diluted coat colour. This mutation dilutes black to blue, chocolate to lilac and yellow to champagne. The mutation tested is the d^2 mutation and is specific to the Chow Chow, Sloughi and Thai Ridgeback breeds. For the other breeds, the test to be performed is the DOG-LOCUS-D test.

Lethal acrodermatitis is a genetic disease of the immune system. The clinical signs are skin lesions on the paws and muzzle, leading to secondary infections. In addition, the lesions cause hyperkeratosis of the pads and deformation of the nails. Affected puppies also suffer from diarrhea, bronchopneumonia and retarded growth. The first symptoms appear quickly after birth. Affected puppies usually die before 2 years of age or are euthanized.

Golden Retriever muscular dystrophy is a homologue of Duchenne muscular dystrophy in humans. Affected dogs develop clinical signs at 8 to 10 weeks of age. Symptoms include a shuffling gait, inability to fully open the jaw, difficulty eating, curvature of the spine and ribs, resulting in a squatted posture. he disease is transmitted in an X-linked recessive manner, so males carrying the mutation will all be affected. However, only females with 2 copies of the mutated allele will be affected.

This package includes the mandatory tests defined by the Flemish breeding program for Miniature American Shepherd: Collie eye anomaly (DOG-CEA), Cataract (DOG-HSF4-BA), Multidrug Resistance 1 (DOG-MDR1), Degenerative myelopathy 2 (DOG-DM2), Coat color merle (DOG-LOCUS-M), Progressive rod-cone degeneration (DOG-PRA-PRCD), Progressive retinal atrophy (DOG-PRA-BBS2), Neuroaxonal dystrophy (DOG-NAD-MAS) and Progressive retinal atrophy 4 (CORD1) (DOG-PRA-CRD4). The Flemish breeding program also recommends the tests included in our package DOG-BGAM-VL+.