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Gangliosidosis is characterised by muscle tremors and loss of motor control. The first symptoms are observed at around 6-8 weeks of age and start with slight tremors that result in feeding difficulties and lack of coordination.

This test is also recommended for Bombay and Australian Mist as part of the breeding program established by the Flemish government (see official program).

Primary ciliary dyskinesia is an inherited disorder described in Alaskan Malamutes. It disrupts the function of motile cilia, which are essential for the natural clearance of the airways. Affected dogs mainly show chronic respiratory problems, including nasal discharge, productive cough, bronchial infections and long-term bronchial damage. This form may also be associated with hydrocephalus, reported in one affected case.

GM2 gangliosidosis is an inherited disease caused by a deficiency of the enzyme β-hexosaminidase, leading to the accumulation of GM2 gangliosides in the nervous system.
In Korat cats, the first signs appear as early as 4 to 6 weeks of age with fine head tremors.
The disease progresses quickly with coordination problems, falls, and abnormal gait.
Affected kittens show severe deterioration over the following months.
Sadly, the outcome is fatal before 8 months of age.

 

Ichthyosis type 2 is a skin condition caused by keratin dysfunction. The skin of affected dogs is dry, thick, scaly with large skin scales. 

In addition to the genetic test available for this form, a specific test is also available for ichthyosis type 1.

Degenerative myelopathy is a neurodegenerative disease that progresses slowly and has a late onset (8 years or more). The initial clinical sign is characterised by hind limb ataxia. As the disease progresses, the frequently observed asymmetric weakness rises to affect the thoracic limbs, resulting in paraplegia. The majority of DM2/DM2 animals will not develop symptoms, however, elimination of these animals from breeding patterns reduces the genetic variability of the breed, which is why Progenus does not recommend this test.

This test is also mandatory as part of the Flemish government's breeding program for the following breeds: Afghan Hound

Polyneuropathy type 1 (LNP21) is a progressive neuromuscular disease characterised by generalised weakness, hypotonia, laryngeal paralysis and muscle atrophy, particularly of the hind limbs. The age of onset of symptoms can vary between 1 and 11 years.

In donkeys, dominant white corresponds to complete depigmentation: the animal is born with a white coat, pink skin and dark eyes. A variant in the KIT gene, c.662A>C, was identified in a donkey showing this phenotype and is considered a candidate variant associated with dominant white. The genetic test can be used to detect this variant and identify animals that carry it. However, the available data remain preliminary, as this variant was observed in only one white donkey in the study.

Spongy degeneration with cerebellar ataxia 2 is a neurodegenerative disorder of the cerebellum. Affected puppies show ataxia with motor disorders, muscle spasms and loss of balance. Following the progression of symptoms, puppies are usually euthanised before 4 months of age.

Narcolepsy is a genetic disorder caused by a mutation in the orexin receptor. Affected dogs are sleepy and cannot stay awake for long periods. The first signs appear between 4 weeks and 6 months. Narcolepsy is not life-threatening.

L-2-hydroxyglutaric aciduria is a genetic disease of the nervous system. The clinical signs are high levels of L-2-hydroxyglutaric acid in urine and plasma, seizures, wobbly gait, ataxia, tremors and muscle stiffness and usually appear from 6 months of age.