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Feline hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy. Symptoms are variable from individual to individual and include heart failure, fatigability and in some cases death of the animal. The causative mutation is different between breeds. HCM4 is specific for the Sphynx.

In donkeys, dominant white corresponds to complete depigmentation: the animal is born with a white coat, pink skin and dark eyes. A variant in the KIT gene, c.662A>C, was identified in a donkey showing this phenotype and is considered a candidate variant associated with dominant white. The genetic test can be used to detect this variant and identify animals that carry it. However, the available data remain preliminary, as this variant was observed in only one white donkey in the study.

Rod-cone dysplasia 4 is one of several forms of progressive retinal atrophy (PRA). This mutation leads to the late onset of PRA, with blindness occurring after 7 years of age.

Hypocatalasia (or acatalasemia) is a rare genetic disorder caused by a mutation in the CAT gene, leading to a severe deficiency of catalase. This enzyme normally protects tissues against oxidative stress. The c.979G>A (p.Ala327Thr) mutation was first identified in a Beagle colony and subsequently detected in pet Beagles. A homozygous dog notably developed oral cavity gangrene with tooth loss at a young age. The disease may remain clinically silent for a long time, which highlights the importance of genetic screening in breeding dogs.
This test is also recommended for the Basset Hound as part of the Flemish government breeding program (see the official program).

The PPARD gene is involved in mechanisms related to energy metabolism, fat utilisation and muscular endurance. In racing pigeons, a recent study suggests that certain variations in this gene may be linked to race performance, particularly return speed and ranking coefficient. The CC genotype for the PPARD c.*271C>T marker is the one that stands out most favourably in the study, notably because it was observed in pigeons taking part in a larger number of races. This test can therefore provide complementary information to guide the selection of breeding birds, without replacing the assessment of the pigeon, its lineage, training and actual racing results.

Progressive retinal atrophy 4, also known as CORD1, is a form of progressive retinal atrophy characterised by changes in the granular appearance of the fundus, followed by generalised tapetal hyperreflexia and retinal vascular attenuation with progressive extinction of the electroretinogram. CORD1 pathology is probably caused by a combination of mutations. Only the mutation in the RPGRIP1 gene is being tested.

This test is also mandatory as part of the Flemish government's breeding program for the following breeds: Airedale Terrier,

Hair length in cats is primarily determined by the FGF5 gene, which plays a role in regulating hair growth. Several mutations in this gene are associated with long hair, following an autosomal recessive mode of inheritance. A cat may have long hair when it carries two copies of variants associated with this trait, either identical or different. Genetic testing identifies the mutations screened for and detects short-haired cats carrying the long-hair trait, providing useful information for predicting coat length in kittens.

This package includes the mandatory tests defined by the Flemish breeding program for Lagotto Romagnolo: Progressive retinal atrophy 4 4 (CORD1) (DOG-PRA-CRD4), Benign familial juvenile epilepsy (DOG-BFJE) et la maladie de surcharge lysosomale (DOG-LSD). The Flemish breeding program also recommends the tests included in our package DOG-LR-VL+.

Hereditary ataxia is a genetic disease causing a degeneration of the nerve cells. The symptoms of this pathology are progressive motor disorders leading to an inability to walk as well as a proprioceptive deficit of the hind limbs. The first clinical signs usually appear between 4 and 19 months of age.

Leukoencephalomyelopathy is a neurodegenerative disease characterised by a progressive loss of mobility and coordination of the limbs. The first symptoms usually appear between 1 and 4 years of age.