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In donkeys, dominant white corresponds to complete depigmentation: the animal is born with a white coat, pink skin and dark eyes. A variant in the KIT gene, c.662A>C, was identified in a donkey showing this phenotype and is considered a candidate variant associated with dominant white. The genetic test can be used to detect this variant and identify animals that carry it. However, the available data remain preliminary, as this variant was observed in only one white donkey in the study.

Palmoplantar Keratoderma is a genetic condition that typically appears between 10 weeks and 1 year of age. Affected dogs develop painful thickening of the paw pads, with keratinous proliferations and fissures localized to the areas in contact with the ground. These fissures can lead to secondary infections and may cause lameness or reluctance to walk. The nails and other areas of the skin do not appear to be affected, and no other associated skin signs have been reported.

Multifocal retinopathy is an eye disease with symptoms appearing between 11 and 16 weeks of age. Affected dogs have multiple circular areas of retinal detachment. Fluid accumulates under the detached retina, resulting in blistering of the eye. The disease progresses slowly and does not usually lead to blindness.

The colorpoint mutation is associated with the production of temperature sensitive pigments. Pigment production is reduced in the warmer areas of the body, resulting in darker pigmentation in the cooler extremities of the cat (paws, ears, etc.). In the Siamese phenotype, pigment expression is limited to the extremities of the cat (legs, tail, ears, face). In the Burmese phenotype, the pigment expression results in a wider distribution of pigments on the body and darker spots than the body.

Hypocatalasia (or acatalasemia) is a rare genetic disorder caused by a mutation in the CAT gene, leading to a severe deficiency of catalase. This enzyme normally protects tissues against oxidative stress. The c.979G>A (p.Ala327Thr) mutation was first identified in a Beagle colony and subsequently detected in pet Beagles. A homozygous dog notably developed oral cavity gangrene with tooth loss at a young age. The disease may remain clinically silent for a long time, which highlights the importance of genetic screening in breeding dogs.
This test is also recommended for the Basset Hound as part of the Flemish government breeding program (see the official program).

The PPARD gene is involved in mechanisms related to energy metabolism, fat utilisation and muscular endurance. In racing pigeons, a recent study suggests that certain variations in this gene may be linked to race performance, particularly return speed and ranking coefficient. The CC genotype for the PPARD c.*271C>T marker is the one that stands out most favourably in the study, notably because it was observed in pigeons taking part in a larger number of races. This test can therefore provide complementary information to guide the selection of breeding birds, without replacing the assessment of the pigeon, its lineage, training and actual racing results.

Sex-linked orange coat colour in cats is associated with an approximately 5 kb deletion in the ARHGAP36 gene, located on the X chromosome. This variant causes abnormal ARHGAP36 expression in melanocytes, reducing the production of eumelanin, the black-brown pigment, and promoting pheomelanin, which is responsible for orange coloration. Males, which have only one X chromosome, are orange when they carry the O variant, whereas they do not show this colour when the variant is absent. In females, two copies of the variant produce an orange coat, while a single copy leads to mosaic expression of orange and non-orange areas, resulting in tortoiseshell or calico coat patterns.

Multifocal retinopathy is an eye disease with symptoms appearing between 11 and 16 weeks of age. Affected dogs have multiple circular areas of retinal detachment. Fluid accumulates under the detached retina, resulting in blistering of the eye. The disease progresses slowly and does not usually lead to blindness.

This test is also recommended for Boxer, Boston Terrier, Cairn Terrier, Jack Russel Terrier, Pyrenean Mountain Dog, Miniature Spitz, Rhodesian Ridgeback as part of the breeding program established by the Flemish government (see official program).