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Hypocatalasia (or acatalasemia) is a rare genetic disorder caused by a mutation in the CAT gene, leading to a severe deficiency of catalase. This enzyme normally protects tissues against oxidative stress. The c.979G>A (p.Ala327Thr) mutation was first identified in a Beagle colony and subsequently detected in pet Beagles. A homozygous dog notably developed oral cavity gangrene with tooth loss at a young age. The disease may remain clinically silent for a long time, which highlights the importance of genetic screening in breeding dogs.
This test is also recommended for the Basset Hound as part of the Flemish government breeding program (see the official program).

Narcolepsy is a genetic disorder caused by a mutation in the orexin receptor. Affected dogs are sleepy and cannot stay awake for long periods. The first signs appear between 4 weeks and 6 months. Narcolepsy is not life-threatening.

Osteogenesis imperfecta, also known as brittle bone disease, is characterised by extreme fragility of bones and teeth caused by an abnormal collagen structure.

Ce profil reprend les analyses spécifiques à effectuer chez le teckel: l'ostéogénèse imparfaite (DOG-OSTEO-T) et la dystrophie des cônes et des bâtonnets (DOG-CRD-SWHD).

This pack includes the recommended tests defined by the Flemish breeding program for Dachshund: Osteogenesis imperfecta (DOG-OSTEO-T), Degenerative myelopathy 2 (DOG-DM2) and Acral Mutilation Syndrome(DOG-AMS). The Flemish breeding program also makes the tests included in our package mandatory DOG-TECK-VL.

This package includes the mandatory tests defined by the Flemish breeding program for Dachshund: Progressive retinal atrophy 4 (CORD1) (DOG-PRA-CRD4), Coat color merle (DOG-LOCUS-M) and Progressive retinal atrophy (NECAP1) (DOG-PRA-NECAP1). The Flemish breeding program also recommends the tests included in our package. DOG-TECK-VL+.

Progressive retinal atrophy is characterised by the relatively early loss of cone photoreceptors while maintaining rod functionality. The first clinical signs appear around the age of 1 to 2 years, progressing to complete blindness.

Neuronal ceroid lipofuscinoses (NCLs) are a group of lysosomal storage diseases that affect the central nervous system, leading to early neuronal death and progressive neurodegeneration. NCL2 specifically affects dachshunds, with symptoms including vision loss, tremors, and coordination problems starting at a young age. Unfortunately, there is no known cure for NCL2, and affected dogs typically do not survive past 12 months of age.

In the Giant Schnauzer, a specific form of progressive retinal atrophy (PRA) is associated with a mutation in the NECAP1 gene. The first symptoms typically appear around the age of 4. This disease is characterized by progressive retinal degeneration leading to blindness.

This test is also mandatory for Dachshunds and Pomeranians as part of the Flemish government's breeding program (see the official program).

Long hair is caused by mutations in the fibroblast growth factor-5 (FGF5) gene. To date, five mutations have been identified. The longhair test identifies the p.Cys95Phe mutation, which is the most common across breeds. The shorthair allele (L) is dominant over the longhair allele (l), so two copies of the longhair allele are required to produce longhaired dogs. The specific test for the Akita breed is available: see Longhair test - Akita (DOG-LHA)